Analysis software of DaT-scan images
DaTsoft3D®
Quantification tool for striatal SPECT images
dedicated to quantitative clinical studies of Parkinson's syndromes
Self-calibration of partial
volume effect correctionDaTsoft3D is able to automatically adapt it-self to the spatial resolution of DaT-scan images. The quantification values obtained are less dependent on the blurr, making it a useful tool for clinical studies.
High performances
and easy to use95% of sensitivity and specificity for the classification of healthy subjects versus Parkinson's disease patients based on the PPMI* international multicentre database.
Gives meaning to quantification
by graphically locating the results from a database
White circle shows values obtained from the image of examined subject. Results from healthy subjects (green dots) and Parkinsonian subjects (red dots) of the PPMI* database are also displayed
A Parkinson Index (PI) is computed depending on putaminal binding ratios, the right / left asymmetry and age. PI value is displayed according to healthy subjects and Parkinson's patients PI distributions of the PPMI* database.
DaTsoft3D® features
Data
Opening DaT-scan images in DICOM format, for one file or several files (for clinical studies)
Reconstruction
Tomographic reconstruction by OSEMR iterative method for parallel collimation (fan-beam according to camera)
Quantification
Semi-automatic registration on an extended 3D striatal model
Quantification of binding potential using partial volume effect correction
Visualization
Simultaneous visualization of 3 planes and slice-by-slice visualisation (transverse or sagittal or coronal).
Quantitative colour scales, with normalization based on the reference activity
Display the binding potentials of caudate nuclei and putamens with modified colour if the value is below the norm.
2D graphs: Putamens vs Caudate nuclei and Putamens vs Dissymmetry
1D graphs: Parkinson's Index taking into account subjects' age
Ability to add 2D graphics to a local database after quantification by DaTsoft3D
Outputs
Automatically save results in a CSV file readable by Excel® for statistical analysis
Prints a screenshot with an automatic backup
Try out DaTsoft3D
Free trial license for 1 month**
Download the installation file for Windows PC
When running for the first time, the software will generate a license request file you must send us
In return, you will receive within 48 hours your trial license valid for 1 month
FAQ
Can I install DaTsoft3D on any computer?
DaTsoft3D doesn’t depend on the gamma camera manufacturers. It works on computers with Windows® operating systems, versions 7 and higher. You must have administrator rights to install it. It requires 600 MB of RAM to run.
How easy is it to adopt DaTsoft3D?
It is very easy, it only takes a few minutes to go through the basic features.
Is any documentation available?
Yes, the software comes with a documentation which provides details on the action of each mouse click on the interface.
How long has this software been used in hospitals?
DaTsoft3D was installed in France in 2013 at Toulouse Purpan University Hospital Centre and at Marseille University Hospital Centre. Since then, it has also been installed in several other hospitals. Several thousand quantifications have been carried out with this software for clinical studies.
More informations are available in the french section.
Publications
Articles et communications
Dopamine transporter imaging for the diagnosis of multiple system atrophy cerebellar type,
S Vergnet, F Hives, A Foubert-Samier, P Payoux, P Fernandez, M Meyer, J Dupouy, C Brefel-Courbon, F Ory-Magne, O Rascol, F Tison, A Pavy-Le Traon, WG. Meissner, Parkinsonism and Related Disorders, 2019, in pressSystème Veriton : évaluation quantitative sur fantôme de Jaszczak et sur fantôme striatalVeriton system: Quantitative evaluation based on Jaszczak and striatal phantom,
E Cassol, P Gantet, P Payoux, Médecine Nucléaire, 2019, In pressDopaminergic loss in patients suspect of hydrocephalus, E Schmidt, F Ory-Magne, L Balardy, P Gantet, P Payoux, Fluids and Barriers of the CNS 2017, 14 (Suppl 1):A57.
A longitudinal follow-up study of the quantification of dopamine transporters with 123IIoflupane (DaTscan).
H Fayolle, P Gantet, AS Salabert, J Delrieu, C Brefel-Courbon, F Ory-Magne, T Voisin, P Payoux, Médecine Nucléaire, Volume 41, Issue 1, 2017, pp 36-41.Quantification of time-related decline of dopamine transporter from consecutive DaTscan images,
H Fayolle, P Gantet, A Salabert, J Delrieu, C Brefel-Courbon, T Voisin, P Payoux, 29th Annual EANM Congress, Barcelone, octobre 2016Impact of gaussian post-filtering on DaTscan® cerebral SPECT quantitative analysis performance,
L Bosc, D Bourhis, R Abgral, PY Le Roux, P Robin, PY Salain, S Querellou, SNMMI, May 2016, San Diego (California), J Nucl Med, 57, supp 2, pp 36.Quantification auto-calibrée de la neurotransmission dopaminergique en TEMP : évaluation de DaTsoft3D,
P Gantet, E Guedj, P Payoux, 52ème colloque de médecine nucléaire de langue française, St Etienne, mai 2014. Médecine Nucléaire, 2014, 38, 3, pp 33.DaTsoft3D: Self-calibrated software for dopamine transporter quantification in SPECT imaging - preliminary results,
P Gantet, E Guedj, P Payoux, 3rd European Conference on Clinical Neuroimaging, Lille, mars 2014.
*About PPMI Database
PPMI – a public-private partnership – is funded by the Michael J. Fox Foundation for Parkinson’s Research and funding partners, including: Abbvie, AVID, Biogen Idec, Biolegend, Bristol-Myers Squibb, GE Healthcare, Genentech, GSK, Lilly, Lundbeck, Merck, Mezo Scale Discovery, Pfizer, Piramal, Roche, Sanofi Genzyme, Servier, Takeda, Teva, UCB and Golub Capital. For more information, visit: www.ppmi-info.org.
** About trial licence
Only one trial licence per institution will be granted.
SIREN : 820 787 323 RCS Toulouse, SIRET : 820 787 323 00014, Code APE : 5829C
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